Morbidity and mortality with early pulmonary haemorrhage in preterm neonates.
Monica M. Bennett Ph.D.
Ahmad, K. A., M. M. Bennett, S. F. Ahmad, R. H. Clark and V. N. Tolia (2019). “Morbidity and mortality with early pulmonary haemorrhage in preterm neonates.” Arch Dis Child Fetal Neonatal Ed 104(1): F63-f68.
OBJECTIVE: There are no large studies evaluating pulmonary haemorrhage (PH) in premature infants. We sought to quantify the clinical characteristics, morbidities and mortality associated with early PH. DESIGN: Data were abstracted from the Pediatrix Clinical Data Warehouse, a large de-identified data set. For incidence calculations, we included infants from 340 Pediatrix United States Neonatal Intensive Care Units from 2005 to 2014 without congenital anomalies. Infants <28 weeks' gestation with PH within 7 days of birth were then matched with two controls for birth weight, gestational age, gender, antenatal steroid exposure, day of life 0 or 1 intubation and multiple gestation. RESULTS: From 596 411 total infants, we identified 2799 with a diagnosis of PH. Peak incidence was 86.9 cases per 1000 admissions for neonates born at 24 weeks' gestation. We then identified 1476 infants <28 weeks' gestation with an early PH diagnosis at
