Research Spotlight

Posted July 17th 2020

An update on applications of 3D printing technologies used for processing polymers used in implant dentistry.

Marta Revilla-León, M.S.D.

Marta Revilla-León, M.S.D.

Revilla-León, M., M. Sadeghpour and M. Özcan (2020). “An update on applications of 3D printing technologies used for processing polymers used in implant dentistry.” Odontology 108(3): 331-338.

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Polymer additive manufacturing (AM) technologies have been incorporated in digital workflows within implant dentistry. This article reviews the main polymer AM technologies in implant dentistry, as well as their applications in the field such as manufacturing surgical guides, custom trays, working implant casts, and provisional restorations.


Posted July 17th 2020

A Review of the Applications of Additive Manufacturing Technologies Used to Fabricate Metals in Implant Dentistry.

Marta Revilla-León, M.S.D.

Marta Revilla-León, M.S.D.

Revilla-León, M., M. Sadeghpour and M. Özcan (2020). “A Review of the Applications of Additive Manufacturing Technologies Used to Fabricate Metals in Implant Dentistry.” J Prosthodont Jun 16. [Epub ahead of print.].

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PURPOSE: To review the primary additive manufacturing (AM) technologies used to fabricate metals in implant dentistry and compare them to conventional casting and subtractive methods. METHODS: The literature on metal AM technologies was reviewed, and the AM procedures and their current applications in implant dentistry were collated and described. Collection of published articles about metal AM in dental field data sources: MEDLINE, EMBASE, EBSCO, and Web of Science searched. All studies related to AM technology description, analysis, and evaluation of applications in implant dentistry, including AM titanium (Ti) dental implants, customized Ti mesh for bone grafting techniques, cobalt-chromium (Co-Cr) frameworks for implant impression procedures, and Co-Cr and Ti frameworks for dental implant-supported prostheses were reviewed. RESULTS: Literature has demonstrated the potential of AM technologies to fabricate dental implants, root-analog implants, and functionally graded implants; as well as the ability to fabricate customized meshes for bone grafting procedures. Metal AM technologies provide a reliable method to manufacture frameworks for implant impression procedures. Co-Cr and Ti AM frameworks for implant-supported prostheses provide a clinically acceptable discrepancy at the implant-prostheses interface. CONCLUSIONS: Additional clinical studies are required to assess the long-term clinical performance, biological and mechanical complications, and prosthetic restoration capabilities of additively manufactured dental implants. Moreover, further studies are needed to evaluate their long-term success and survival rates and biological and mechanical complications of AM implant-supported prostheses.


Posted July 17th 2020

Insights into the July 2020 Issue of the Journal of Endodontics.

Gerald N. Glickman, M.S.

Gerald N. Glickman, M.S.

Azarpazhooh, A., A. R. Diogenes, A. F. Fouad, G. N. Glickman, A. Kishen, L. Levin, R. S. Roda, C. M. Sedgley, F. R. Tay and K. M. Hargreaves (2020). “Insights into the July 2020 Issue of the Journal of Endodontics.” J Endod 46(7): 907-908.

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Welcome to the July 2020 issue of the Journal of Endodontics (JOE). Here we share some of our favorite articles that are published in this issue of the journal. We hope you look forward to reading these and other articles in JOE. [No abstract; excerpt from Editorial.].


Posted June 24th 2020

Acute Workplace Hazards in Orthopedic Surgery: Resident Survey Regarding Splash and Workplace Violence Events.

Shawna L. Watson M.D.

Shawna L. Watson M.D.

Yohe, N., S. J. Swiggett, A. Razi, J. R. Bowman, S. L. Watson, J. M. Pearson, P. W. Hudson, J. C. Patt, S. E. Ames, L. R. Leddy, J. G. Khoury, C. C. Tubb, G. McGwin and B. Ponce (2020). “Acute Workplace Hazards in Orthopedic Surgery: Resident Survey Regarding Splash and Workplace Violence Events.” J Surg Educ Jun 3;S1931-7204(20)30142-2. [Epub ahead of print].

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INTRODUCTION: Orthopedic surgery residents are at risk for daily work-related hazards and exposures. Hazards related specific to this specialty includes radiation exposure, smoke inhalation (from electrocautery), and disease transmission through contact with surgical instruments or sharps during procedures. However, minimal research has been focused on other occupational hazard risks in orthopedic surgery including surgical splash events and workplace violence. This study focused on determining (1) whether or not use of protective eyewear in the workplace would be related to the availability of personal protective equipment (PPE); (2) resident education; and (3) the rate of workplace violence toward orthopedic surgery residents during their training. METHODS: An invitation to participate in a web-based, anonymous survey to 46 US allopathic orthopedic surgery residency programs (1207 potential resident respondents). The survey was conceptually divided into the following areas: (1) demographics; (2) training and attitudes concerning occupational hazards; (3) PPE provision and use; (4) sharps injuries and reporting; and (5) general safety knowledge and violence in the workplace. Those who answered yes to having a splatter event or receiving a threat at the hospital were compared to those who did not. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between these outcomes and selected independent variables of interest. p-Values of <0.05 were considered statistically significant. RESULTS: From January 18 to March 31, 2016, 518 surveys were received and included for analysis for a response rate of 42.9% (518/1207). One survey was excluded from analysis due to <50% completed response items. Self-reported program types were 64.5% (334/518) public university-affiliated, 23.2% (120/518) private university affiliated, 7.1% (37/518) community, and 5.2% (27/518) military. Residents were 83.0% = male and 17.0% = female. Overall, reported eye protection usage was 95% amongst all residents and 22% of residents reported experiencing a violent threat in the workplace. The risk of experiencing a splatter event was not statistically associated with residency type, gender, or geographic region. Senior residents were at an increased likelihood of experiencing a splatter event (OR 1.22, [95% CI 1.06-1.41], p = 0.006) when compared to PGY-1 residents. The risk of a violent experience at work was not statistically associated with residency type, year of residency training, or gender. Residents in the Northeast were more likely to have a violent experience (OR 2.78 [95% CI 1.41-5.49] p = 0.003). Overall, residents felt that they had adequate training to prevent occupational hazards (mean of 3.9/5 on Likert scale) and respond to hazards (mean of 3.7/5 Likert). CONCLUSIONS: Occupational hazards are not uncommon in orthopedic surgery training with high rates of improper eyewear PPE use and poor awareness of Occupational Safety and Health Administration and AAOS guidelines. Violence in the workplace impacts over one in 4 residents and training programs and hospitals should improve education and report efforts. Continual yearly PPE training and awareness of AAOS guidelines could be intertwined with duty hour and/or case logs in order to ensure residents are exposed to this material on a regular basis.


Posted June 24th 2020

“(123)I-Iofluopane Single-Photon Emission Computed Tomography as an Imaging Biomarker of Pre-Synaptic Dopaminergic System after Moderate-to-Severe Traumatic Brain Injury.

Marie Dahdah, Ph.D.

Marie Dahdah, Ph.D.

Womack, K. B., R. Dubiel, L. Callender, C. Dunklin, M. Dahdah, T. S. Harris, Devous Md, Sr., S. B. Juengst, K. Bell, R. Diaz-Arrastia and K. Ding (2020). “(123)I-Iofluopane Single-Photon Emission Computed Tomography as an Imaging Biomarker of Pre-Synaptic Dopaminergic System after Moderate-to-Severe Traumatic Brain Injury.” J Neurotrauma June 3. [Epub ahead of print].

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Dopaminergic (DA) system function is frequently disrupted after traumatic brain injury (TBI). However, published interventions that target the DA system with the hope of enhancing functional outcomes are inconclusive, partially because of the lack of DA signaling biomarkers that can be used to select patients likely to benefit from DA-directed therapies or to monitor treatment efficacy. The aim of this study was to evaluate the feasibility of using (123)I-iofluopane single-photon emission computerized tomography (SPECT) to assess pre-synaptic DA system dysfunction after severe TBI. Eighteen patients with severe TBI were enrolled in this study. (123)I-iofluopane SPECT imaging was performed at baseline and again 2.5 h after a single dose of methylphenidate (MP) administered enterally. DA transporter (DAT) specific binding ratio (SBR) before and after MP was measured. Functional outcomes included the Disability Rating Scale, JFK Coma Recovery Scale-Revised, Functional Independence Measure, and Functional Assessment Measure. Thirteen of 18 patients completed the study. Average time from injury to SPECT scan was 48 days (standard deviation [SD], 24 days; median, 31). Baseline ioflupane striatal SBR was 1.51 ± 0.46 (median, 1.67). A 43.1% (SD, 16; median, 46.5) displacement of ioflupane from pre-synaptic DAT was observed after MP administration. Baseline SBR positively correlated with functional status at baseline and 4 weeks after completion of the study. Serum MP levels correlated with relative change in SBR (r(s) = 0.60; p = 0.04). Our findings suggest that (123)I-iofluopane SPECT is a promising tool to determine the severity of pre-synaptic DA terminal disruption and for monitoring pharmacokinetics and pharmacodynamics of therapeutic interventions targeting the DA system.