A Panel of Methylated MicroRNA Biomarkers for Identifying High-Risk Patients With Ulcerative Colitis-Associated Colorectal Cancer.
Ajay Goel Ph.D.
Toiyama, Y., Y. Okugawa, K. Tanaka, T. Araki, K. Uchida, A. Hishida, M. Uchino, H. Ikeuchi, S. Hirota, M. Kusunoki, C. R. Boland and A. Goel (2017). “A panel of methylated microrna biomarkers for identifying high-risk patients with ulcerative colitis-associated colorectal cancer.” Gastroenterology 153(6): 1634-1646.e1638.
BACKGROUND & AIMS: Methylation of specific microRNAs (miRNAs) often occurs in an age-dependent manner, as a field defect in some instances, and may be an early event in colitis-associated carcinogenesis. We aimed to determine whether specific mRNA signature patterns (MIR1, MIR9, MIR124, MIR137, MIR34B/C) could be used to identify patients with ulcerative colitis (UC) who are at increased risk for colorectal neoplasia. CONCLUSIONS: In evaluation and validation cohorts, we found specific miRNAs to be methylated in rectal mucosal samples from patients with UC with dysplasia or CRC compared with patients without neoplasms. This pattern also associated with patient age and might be used to identify patients with UC at greatest risk for developing UC-CRC. Our findings provide evidence for a field defect in rectal mucosa from patients with UC-CRC.